Dr. Gregory Michael, an obstetrician in personal follow at Mount Sinai Medical Heart in Miami Seaside, acquired a primary dose of the Pfizer/BioNTech experimental mRNA COVID-19 vaccine on December 18, 2020 and died 16 days later of a cerebral hemorrhage (stroke).1
Inside three days of taking the shot, he developed signs of a extreme autoimmune bleeding dysfunction, idiopathic thrombocytopenic purpura (ITP), typically referred to as immune thrombocytopenia.2 In accordance with his spouse, the 56-year previous OB/GYN doctor was wholesome when he acquired the COVID-19 vaccine and commenced exhibiting signs of bleeding below the pores and skin inside 72 hours.
He was hospitalized within the intensive care unit however not one of the remedies have been capable of cease the inner bleeding.3 The case is being investigated by the Miami-Dade County health worker, which is working with the U.S. Facilities for Illness Management and Prevention and Florida Division of Well being.4
In accordance to the Miami Herald, as of January 7, 2021, a Pfizer official mentioned Michael died of a “extremely uncommon scientific case of extreme thrombocytopenia, a situation that decreases the physique’s means to clot blood and cease inside bleeding.”
The Pfizer spokesman added, “We’re actively investigating this case however we don’t imagine at the moment that there’s any direct connection to the vaccine.”5 A CBS report quoted the Pfizer spokesman as saying:6
“There have been no associated security alerts recognized in our scientific trials, the post-marketing expertise thus far or with the mRNA vaccine platform. Thus far thousands and thousands of individuals have been vaccinated and we’re carefully monitoring all hostile occasions in people receiving our vaccine.
It is very important notice that critical hostile occasions, together with deaths which are unrelated to the vaccine are sadly prone to happen at an identical fee as they’d within the common inhabitants.”
Spouse: Gregory Michael ‘Liked by Everybody within the Neighborhood’
The well-known and fashionable obstetrician, who was a Miami native, Michael had operated a personal OB/GYN follow in Miami Seaside for 12 years and in addition labored as a scientific teacher and college member for the doctor assistant program at Barry College and Miami Dade School. He was the daddy of a 15-year-old daughter.
His spouse, Heidi Neckelmann, made a heartfelt publish on-line7 calling her husband “the love of my life” who was “beloved by everybody within the neighborhood, delivered a whole bunch of wholesome infants and labored tirelessly by the pandemic.” When informing her mates about his loss of life, she requested them to share her publish so the general public is extra conscious that the COVID-19 vaccine shouldn’t be risk-free. She mentioned:
“He was a professional vaccine advocate and that is why he bought it himself. I imagine that individuals needs to be conscious that facet results can occur, that it isn’t good for everybody and, on this case, destroyed a lovely life, an ideal household, and has affected so many individuals in the neighborhood. Don’t let his loss of life be in useless, please save extra lives by making this info information.”
CDC: ‘Potential Advantages’ of COVID Vaccines ‘Outweigh Dangers’
A CBS report quoted Dr. Nancy Messonnier, director of the CDC’s Nationwide Heart for Immunization and Respiratory Ailments, as saying, “The identified and potential advantages of the present COVID-19 vaccines outweigh the identified and potential dangers of getting COVID-19. That doesn’t imply, nevertheless, that we couldn’t see potential critical well being occasions sooner or later.”
Reportedly, CDC officers instructed reporters that they had not seen any critical reactions past 29 instances of extreme allergic reactions — or about 11 instances of anaphylaxis per 1 million doses of COVID-19 vaccinations administered.8
ITP Brought on by Autoantibody-Mediated Platelet Destruction
Idiopathic or immune thrombocytopenic purpura (ITP) is a posh autoimmune dysfunction attributable to autoantibody-mediated destruction of platelets, that are cells in the blood that assist cease bleeding.9 Principally, the immune system malfunctions and produces antibodies that assault the physique’s platelets. In some instances, T-cells (a kind of white blood cell) will instantly assault and destroy the platelets.10
ITP has been reported to develop after infections, together with SARS-CoV-2 an infection;11 reactions to pharmaceuticals and over-the-counter drugs,12 being pregnant, publicity to chemical toxins,13 vaccination,14 or as a complication of autoimmune problems like rheumatoid arthritis and lupus, however all of the causes of ITP are nonetheless not identified.
A regular platelet depend is between 150,000 to 450,000 platelets and ITP can drive the platelet depend all the way down to lower than 10,000 platelets, which causes important inside bleeding.
Signs of ITP might start with the looks of tiny pink dots below the pores and skin, which point out very small bleeds, and progress to purple blotches and bruises on giant areas of the pores and skin, in addition to nosebleeds, bleeding within the mouth and across the gums, and blood within the vomit, urine or stool, which point out a lot extra critical inside bleeding.
The most harmful complication of ITP is bleeding within the mind inflicting a cerebral hemorrhage and catastrophic mind harm or loss of life.15 Therapies that attempt to gradual or cease the destruction of platelets throughout ITP are restricted and embrace intravenous gamma globulin (IVGG) and platelet infusions, steroids and several other different drugs, or elimination of the spleen.16
ITP in kids, which happens in 1 in 20,000 kids, will be extra simply reversed than ITP in adults, which happens in about 1 in 15,000 adults within the U.S. and is extra widespread in ladies and people over age 60.17,18 The vast majority of kids recuperate from acute ITP however roughly 30% of adults have continual illness after creating ITP and 5% die from hemorrhage.19
ITP Reported After and Causally Associated to Vaccinations
In 1991, an Institute of Drugs committee on the Nationwide Academy of Sciences acknowledged in its report titled “Hostile Results of Pertussis and Rubella Vaccines” that there have been too few scientific research printed within the medical literature investigating ITP following complete cell pertussis (DPT) vaccination or rubella (MMR) vaccination for the committee to find out whether or not or not DPT or MMR vaccine causes ITP in kids.20,21
Nonetheless, experiences continued to be printed within the medical literature.22 In 2001, a examine was printed in Archives of Illness in Childhood confirming a causal affiliation between measles-mumps-rubella vaccine and ITP.
Examine authors mentioned, “Absolutely the threat inside six weeks of immunization was 1 in 22,300 doses, with two of each three instances occurring within the six-week post-immunization interval being attributable to MMR.”23 The CDC’s web site at the moment states:24
“Immune thrombocytopenic purpura (ITP) is a dysfunction that decreases the physique’s means to cease bleeding. It might occur after each pure measles an infection in addition to after getting the MMR vaccine.
Nonetheless, it’s normally not life threatening. Therapy might embrace blood transfusion and drugs. The chance of ITP has been proven to be elevated within the six weeks following an MMR vaccination, with one examine estimating 1 case per 40,000 vaccinated kids.”
Throughout the previous decade, there have been numerous printed research from the U.S. and different nations that ITP develops after receipt of vaccines, together with HPV25 and influenza vaccines,26,27 with authors calling for extra analysis into the affiliation between vaccination and ITP.28,29,30 One group of researchers wanting on the relationship between ITP and vaccinations mentioned in 2014:31
“Vaccines might induce ITP by a number of mechanisms. Vaccine-associated autoimmunity might stem not solely from the antigen-mediated responses but additionally from different constituents of the vaccine, akin to yeast proteins, adjuvants, and preservative diluents. The almost certainly is thru virally induced molecular mimicry …
The autoantibodies speculation shouldn’t be enough to elucidate all ITP instances: Within the anti-platelet antibody-negative instances, a complementary mechanism primarily based on T cell immune-mediated mechanism has been steered. Specifically, T cell subsets appear dysregulated with an elevated manufacturing of pro-inflammatory cytokines, as IFN-y and TNF, and chemokines, as CXCL10.”
An editorial within the October 2020 Worldwide Journal of Infectious Ailments titled “ITP Following Vaccination” identified that “the time period ‘mosaic of autoimmunity’ signifies that immune mediated problems can contain totally different sources, together with genetics, environmental components and hormonal or immune defects.”32
The editors famous that vaccination is among the “environmental triggers” that has been described within the medical literature in affiliation with ITP. The journal editors, who known as for extra analysis into the vaccination-ITP affiliation, acknowledged:33,34
“Whatever the mechanism by which synthetic immunization causes ITP, it has been reported following vaccinations in opposition to numerous infectious brokers, particularly measles-mumps-rubella (MMR), but additionally Haemophilus influenza [HIB], hepatitis B (HBV), human papilloma virus (HPV), varicella zoster [chickenpox], diphtheria-tetanus acellular pertussis (DTap), polio and pneumococcus vaccines.
A French examine that evaluated drug-induced ITP discovered that round 45% of the instances have been post-vaccinal.”
FDA: Moderna COVID-19 Vaccine Trial Had ITP Case
Pfizer didn’t report a case of ITP occurring in scientific trials of its experimental COVID-19 mRNA vaccine, which was the vaccine that Michael acquired.35
Nonetheless, in a briefing doc ready for the December 17, 2020, Vaccines and Associated Organic Merchandise Advisory Committee assembly, the place members of the committee voted on granting Moderna an Emergency Use Authorization (EUA) to distribute its mRNA COVID-19 vaccine within the U.S., the FDA did notice a case of ITP in a 72-year-old scientific trial participant who was hospitalized with thrombocytopenia and obstructive kidney stone illness after receiving the experimental vaccine and died of multiorgan failure.
In discussing deaths that occurred within the Moderna COVID-19 vaccine scientific trials, the FDA acknowledged:36
“One case was a 72-year-old vaccine recipient with Crohn’s illness and brief bowel syndrome who was hospitalized for thrombocytopenia and acute kidney failure attributable to obstructive nephrolithiasis [kidney stone] 40 days after dose 2 and developed problems leading to multiorgan failure and loss of life.”